Medical Research Institute - Department of Life ScienceDivision of Tumor Biology

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研究室集合写真-腫瘍生物

In multicellular organisms the roles and functions of individual cells are strictly regulated to enable survival and reproduction of the organisms. Tumor cells can proliferate and migrate throughout the body until the organism dies. During these steps, tumor cells elaborately utilize the regulation mechanisms that are primarily used in embryonic development, tissue organization, tissue regeneration, and inflammatory response by normal cells. Furthermore, tumor cells can change their characteristics to survive and proliferate under the various microenvironments in tissues and organs. Our purpose is to clarify the mechanism of progression based on these biological characteristics of tumor cells. Without being restricted to a limited concept like “tumor”, we regard all eukaryote, including unicellular organisms such as protozoa, as potential candidates for our research.

Contact Information

TEL: 076-286-2211(Ext.7212) +81-76-286-2211  / FAX: / Email: takahide@kanazawa-med.ac.jp

Faculty

Associate Professor

  • OTA Takahide 研究室代表者-腫瘍生物

Research Achievements

Research Activities

  • Ota, T., Maeda, M., Okamoto, M., Tatsuka, M. Positive regulation of Rho GTPase activity by RhoGDIs as a result of their direct interaction with GAPs. BMC systems biology, 9: 3, 2015.
  • Okamoto, M., Fujiwara, M., Hori, M., Okada, K., Yazama, F., Konishi, H., Xiao, Y., Qi, G., Shimamoto, F., Ota, T. Temme, A., Tatsuka, M., tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells. PLoS genetics 10(9): e1004639, 2014.
  • Jiang, Y.-S., Maeda, M., Okamoto, M., Fujii, M., Fukutomi, R., Hori, M., Tatsuka, M., Ota, T. Centrosomal localization of RhoGDIβ and its relevance to mitotic processes in cancer cells. Int. J. Oncol., 42(2): 460-468, 2013.
  • Hori, M., Miki, T., Okamoto, M., Yazama, F., Konishi, H., Kaneko, H., Shimamoto, F., Ota, T., Temme, A., Tatsuka, M. The detergent-soluble cytoplasmic pool of survivin suppresses anoikis and its expression is associated with metastatic disease of human colon cancer. PLoS ONE 8(2): e55710, 2013.
  • Fujikawa-Yamamoto, K., Ota, T., Miyagoshi, M., Yamagishi, H. Pluripotency of a polyploid H1 (ES) cell system without leukaemia inhibitory factor. Cell Prolif. 45(2): 140-147, 2012.

External Research Funding

  • Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, Scientific Research C (General), (20591596), FY 2008, 2009, 2010, ¥4,550,000, Analysis of function of RhoGDIβ in the regulation of cell polarity and progression in colon cancer. Principal Investigator, Takahide Ota.
  • Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, Scientific Research C (General), (16590642), FY 2004, 2005, ¥3,600,000, Investigation of the regulation mechanism of metastasis by RhoGDI in colon cancer. Principal Investigator, Takahide Ota.
  • Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, Scientific Research C (General), (14571162), FY 2002, 2003, ¥4,000,000, Role of Eomes, a key regulator for mesoderm differentiation, in progression of colon cancer cells. Principal Investigator, Takahide Ota.
  • Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science, Scientific Research C (General), (12671182), FY 2000, 2001, ¥1,900,000, Molecular genetical analysis of functions of integrins and D4GDI during intravasation of cancer cells. Principal Investigator, Takahide Ota.
  • Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, Scientific Research C, (07670260), FY 1995, 1996, ¥2,400,000, Molecular buiological approach for identifying cancer metastasis-relating genes. Principal Investigator, Takahide Ota.